It was in the Long Acre / Covent Garden area of london that Margaret Murphy first started her work and join the newly founded “Congregation of the Poor Servants of the Mother of God”. It was here that she took the name Sister Francis in 1870. This was a particularly poor area of London at the time. The address of the convent was Number 2 Castle Street, Long Acre.
In 1888 Mother Frances Murphy began a new ministry, now known as "Franciscan Sisters Minoress", in London committed to the helping the destitute. Her work included visiting Homes, nursing, religeous instruction and working in an orphanage.